The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities
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چکیده
منابع مشابه
The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities
During early embryogenesis of both vertebrates and invertebrates, antagonism between bone morphogenetic proteins (BMPs) and several unrelated secreted factors including Chordin (Chd) is a general mechanism by which the dorso-ventral axis is established. High affinity binding of Chd sequesters the BMP ligands in the extracellular space, preventing interactions with their membrane receptors. Anot...
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Survivin is a member of the inhibitor of apoptosis protein (IAP) family that is believed to play a role in oncogenesis. To elucidate further its physiologic role(s), we have characterized the murine survivin gene and complementary DNA (cDNA). The structural organization of the survivin gene, located on chromosome 11E2, is similar to that of its human counterpart, both containing 4 exons. Surpri...
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OBJECTIVE Preeclampsia and small-for-gestational age (SGA) neonates have partially overlapping clinicopathologic features. MicroRNAs (miRNAs) are critical posttranscriptional regulators of gene expression. This study was performed to determine whether preeclampsia and SGA are associated with alterations in placental miRNA expression. STUDY DESIGN Placentas were obtained from patients with (1)...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2001
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(01)00423-3